SJF 1528

Tocris Bioscience | Catalog # 7262

Potent EGFR PROTAC® Degrader; also degrades HER2
Tocris Bioscience

Key Product Details

Description

Potent EGFR PROTAC® Degrader; also degrades HER2
View all Active Degraders »

Product Description

SJF 1528 is a potent EGFR PROTAC® Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. SJF 1528 comprises the EGFR inhibitor Lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

EGFR antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF231

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for SJF 1528

Molecular Weight

1030.61

Formula

C55H57ClFN7O8S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2230821-38-0

PubChem ID

135157151

InChI Key

ZSCOIFSUFMYZEZ-YSWDPXALSA-N

SMILES

CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOC4=CC=C(C5=CC6=C(N=CN=C6NC7=CC(Cl)=C(C=C7)OCC8=CC(F)=CC=C8)C=C5)C=C4)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 103.06 100

Preparing Stock Solutions for SJF 1528

The following data is based on the product molecular weight 1030.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.97 mL 4.85 mL 9.70 mL
5 mM 0.19 mL 0.97 mL 1.94 mL
10 mM 0.10 mL 0.49 mL 0.97 mL
50 mM 0.02 mL 0.10 mL 0.19 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SJF 1528

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJF 1528

For research use only

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