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SKF 83566 hydrobromide

Catalog #: 1586
10 Citations Datasheet / COA / SDS
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1586/10
SKF 83566 hydrobromide | CAS No. 108179-91-5 | Dopamine D1 and D5 Receptor Antagonists
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Description: Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2

Chemical Name: 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide

Purity: ≥98%

Product Details
Citations (10)
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Biological Activity

SKF 83566 hydrobromide is a potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
413.15
Formula:
C17H18BrNO.HBr
Solubility:
Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
108179-91-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SKF 83566 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SKF 83566 hydrobromide include:

10 Citations: Showing 1 - 10

  1. DA-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons.
    Authors: Li Et al.
    J Neurochem  2017;140:550
  2. Activation of DRD5 inhibits tumor growth by autophagic cell death.
    Authors: Leng Et al.
    Autophagy  2017;13:1404
  3. DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Hum Mol Genet  2015;9:310
  4. A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila.
    Authors: Cassar Et al.
    Learn Mem  2015;24:197
  5. Regionally selective requirement for D1/D5 DArgic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
    Authors: Savalli Et al.
    J Neurosci  2015;22:69
  6. D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus.
    Authors: Huang Et al.
    Learn Mem  2014;21:153
  7. DA receptors in human embryonic stem cell neurodifferentiation.
    Authors: Belinsky Et al.
    Stem Cells Dev  2013;22:1522
  8. Leptin reduces food intake via a DA D2 receptor-dependent mechanism.
    Authors: Billes Et al.
    Mol Metab  2012;1:86
  9. D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.
    Authors: Stramiello
    Neuropharmacology  2008;55:871
  10. Increased DA level enhances male-male courtship in Drosophila.
    Authors: Liu Et al.
    World J Gastroenterol  2008;28:5539

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