SLIGKV-NH2

Catalog #: 3010
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3010/5

1 Image

Description: PAR2 receptor agonist

Purity: ≥95%

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Product Details

Citations (1)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SLIGKV-NH2 is a protease-activated receptor 2 (PAR₂) agonist (K_i = 9.64 μM and IC₅₀ = 10.4 μM). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2.

Control Peptide also available.

Technical Data

M.Wt:

614.78

Formula:

C₂₈H₅₄N₈O₇

Sequence:

SLIGKV

(Modifications: Val-6 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

190383-13-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Control Peptide Available

Background References

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
Nomura K, Obata K, Keira T, Miyata R, Hirakawa S, Takano K, Kohno T, Sawada N, Himi T, Kojima T
Respir Res, 2014;15(0):21.
Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.
Bohm et al.
Biochem.J., 1996;314:1009
International union of pharmacology XXVIII. Proteinase-activated receptors.
Hollenberg and Compton
Pharmacol.Rev., 2002;54:203
Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [³H]2-furoyl-LIGRL-NH₂, to human PAR2.
Kanke et al.
Br.J.Pharmacol., 2005;145:255

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for SLIGKV-NH2

The citations listed below are publications that use Tocris products. Selected citations for SLIGKV-NH2 include:

1 Citation: Showing 1 - 1

Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET
Authors: Namkung Et al.
Nature Communications 2016;7:12178

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