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SLIGRL-NH2

Catalog #: 1468
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1468/1
SLIGRL-NH2
1 Image
Description: PAR2-activating peptide

Purity: ≥95%

Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SLIGRL-NH2 is an agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in mice in vivo.

Control Peptide also available.

Technical Data

M.Wt:
656.82
Formula:
C29H56N10O7
Sequence:
SLIGRL

(Modifications: Leu-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
171436-38-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. HAT1 induces lung cancer cell apoptosis via up regulating Fas
    N Han, L Shi, Q Guo, W Sun, Y Yu, L Yang, X Zhang, M Zhang
    Oncotarget, 2017;8(52):89970-89977.
  2. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle.
    Al-Ani et al.
    Can.J.Physiol.Pharmacol., 1995;73:1203
  3. In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse.
    Kawabata et al.
    Br.J.Pharmacol., 2001;133:1213
  4. Molecular cloning of a potential proteinase activated receptor.
    Nystedt et al.
    Proc.Natl.Acad.Sci.U.S.A., 1994;91:9208

Product Datasheets

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Citations for SLIGRL-NH2

The citations listed below are publications that use Tocris products. Selected citations for SLIGRL-NH2 include:

7 Citations: Showing 1 - 7

  1. Virus envelope tissue factor promotes infection in mice.
    Authors: Sutherland Et al.
    J Thromb Haemost  2019;17:482
  2. A central role for R7bp in the regulation of itch sensation.
    Authors: Pandey Et al.
    Pain  2017;158:931
  3. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci  2014;55:3912
  4. Protease activated receptor-2 contributes to heart failure.
    Authors: Antoniak Et al.
    EMBO J  2013;8:e81733
  5. TRPV1-lineage neurons are required for thermal sensation.
    Authors: Mishra Et al.
    PLoS One  2011;30:582
  6. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
    Authors: Vellani Et al.
    Mol Pain  2010;6:61
  7. Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells.
    Authors: Vidwan Et al.
    Arterioscler Thromb Vasc Biol  2010;30:2587

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