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Spautin 1

Catalog #: 5197
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5197/50
5197/10
Spautin 1 | CAS No. 1262888-28-7 | Deubiquitinating Enzyme Inhibitors
1 Image
Description: USP10 and USP13 inhibitor; inhibits autophagy

Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

Technical Data

M.Wt:
271.26
Formula:
C15H11F2N3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1262888-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.
    Salabei et al.
    Biochem.J., 2013;451:375
  2. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
    Liu et al.
    Cell, 2011;147:223
  3. Targeting oncoproteins with a positive selection assay for protein degraders
    V Koduri, L Duplaquet, BL Lampson, AC Wang, AH Sabet, M Ishoey, J Paulk, M Teng, IS Harris, JE Endress, X Liu, E Dasilva, JA Paulo, KJ Briggs, JG Doench, CJ Ott, T Zhang, KA Donovan, ES Fischer, SP Gygi, NS Gray, J Bradner, JA Medin, SJ Buhrlage, MG Oser, WG Kaelin
    Science Advances, 2021;7(6):.

Product Datasheets

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Citations for Spautin 1

The citations listed below are publications that use Tocris products. Selected citations for Spautin 1 include:

3 Citations: Showing 1 - 3

  1. USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity.
    Authors: Ji Eun Et al.
    Mol Med  2022;28:164
  2. Targeting oncoproteins with a positive selection assay for protein degraders.
    Authors: Tinghu Et al.
    Sci Adv  2021;7
  3. Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle.
    Authors: Catarina Et al.
    J Cell Physiol  2020;235:7370-7382

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