SR 11237
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid
Purity: ≥98%
Biological Activity
SR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity.
Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L
Biochem Biophys Res Commun, 2014;454(4):537-542. -
Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.
Chiba et al.
Mol.Cell.Biol., 1997;17:3013 -
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
Benoit et al.
EMBO J., 1999;18:7011 -
Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.
Zhou et al.
Mol.Cell.Biochem., 2010;335:283
Product Datasheets
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Citation for SR 11237
The citations listed below are publications that use Tocris products. Selected citations for SR 11237 include:
1 Citation: Showing 1 - 1
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Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.
Authors: Halstead Et al.
Elife 2017;6
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