SR 13800
Chemical Name: 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
Purity: ≥98%
Biological Activity
SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking
S Maacha, J Hong, A von Lersne, A Zijlstra, A Belkhiri
Neoplasia, 2018;20(10):1008-1022. -
Monocarboxylate transporter MCT1 is a target for immunosuppression.
Murray et al.
Nat.Chem.Biol., 2005;1:371 -
Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors.
Wang et al.
J.Med.Chem., 2014;57:7317
Product Datasheets
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Citations for SR 13800
The citations listed below are publications that use Tocris products. Selected citations for SR 13800 include:
4 Citations: Showing 1 - 4
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Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models.
Authors: Alejandra Et al.
Int J Mol Sci 2023;24
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A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer.
Authors: Joselyn Et al.
Cells 2022;11
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AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking.
Authors: Maacha Et al.
Neoplasia 2018;20:1008
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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.
Authors: Liu Et al.
Cell Metab 2017;26:719
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