SR 140333
Chemical Name: 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
Purity: ≥97%
Biological Activity
SR 140333 is a potent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM). Inhibits substance P-invoked calcium mobilization and outward current (IC50 = 1.3 nM); blocks NK1-mediated nitric oxide-dependent vasodilation in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line.
Oury-Donat et al.
J.Neurochem., 1994;62:1399 -
In vitro and in vivo biological activities of SR140333, a novel non-peptide tachykinin NK1 receptor antagonist.
Emonds-Alt et al.
Eur.J.Pharmacol., 1993;250:403 -
Inhibition by SR140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilation in the hamster cheek pouch microvasculature in vivo.
Hall and Brain
Br.J.Pharmacol., 1994;113:522 -
Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of Caj
Nieuwmeyer et al.
J.Pharmacol.Exp.Ther., 2006;317:439
Product Datasheets
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Citation for SR 140333
The citations listed below are publications that use Tocris products. Selected citations for SR 140333 include:
1 Citation: Showing 1 - 1
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A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.
Authors: Xinzhong Et al.
Neuron 2019;101:412-420.e3
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