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SR 2211

Catalog #: 4869
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4869/10
SR 2211 | CAS No. 1359164-11-6 | ROR / NR1F Inverse Agonists
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Description: Selective RORγ inverse agonist

Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Technical Data

M.Wt:
527.48
Formula:
C26H24F7N3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1359164-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Scripps Research Institute.

Background References

  1. Identification of SR2211: a potent synthetic RORγ-selective modulator.
    Kumar et al.
    ACS Chem.Biol., 2012;7:672

Product Datasheets

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Citations for SR 2211

The citations listed below are publications that use Tocris products. Selected citations for SR 2211 include:

3 Citations: Showing 1 - 3

  1. Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling.
    Authors: Hong-Wu Et al.
    Cancers (Basel)  2021;13
  2. Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter.
    Authors: Brian T Et al.
    Front Immunol  2021;12:715059
  3. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.
    Authors: Peter D Et al.
    Cell  2019;177:572-586.e22

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