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SR 8278

Catalog #: 4463
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4463/10
4463/50
SR 8278 | CAS No. 1254944-66-5 | Nuclear Receptor Antagonists
1 Image
Description: Rev-Erbα antagonist

Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.

Technical Data

M.Wt:
361.48
Formula:
C18H19NO3S2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1254944-66-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
    Kojetin et al.
    ACS Chem.Biol., 2011;6:131

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Citations for SR 8278

The citations listed below are publications that use Tocris products. Selected citations for SR 8278 include:

4 Citations: Showing 1 - 4

  1. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway.
    Authors: Ning Et al.
    Cell Death Dis  2023;14:51
  2. Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson's Disease Model.
    Authors: Hyun Ok Et al.
    Biomol Ther (Seoul)  2022;30:409-417
  3. Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.
    Authors: Hanne M Et al.
    Sci Rep  2022;12:17856
  4. Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
    Authors: Parker Et al.
    Cell  2017;168:527

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