Home / LXR-like Receptor Inverse Agonists / SR 9238

SR 9238

Catalog #: 5854
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5854/10
5854/50
SR 9238 | CAS No. 1416153-62-2 | LXR-like Receptor Inverse Agonists
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Description: Potent and selective LXR inverse agonist

Chemical Name: Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SR 9238 is a potent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice.

Technical Data

M.Wt:
595.73
Formula:
C31H33NO7S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1416153-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A liver-selective LXR inverse agonist that suppresses hepatic steatosis.
    Griffett et al.
    ACS Chem.Biol., 2013;8:559

Product Datasheets

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Citations for SR 9238

The citations listed below are publications that use Tocris products. Selected citations for SR 9238 include:

2 Citations: Showing 1 - 2

  1. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway.
    Authors: Ning Et al.
    Cell Death Dis  2023;14:51
  2. PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells.
    Authors: Bruschi Et al.
    Hepatol Commun  2019;3:1191

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