STF 31
Chemical Name: 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
Purity: ≥99%
Biological Activity
STF 31 is an inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
NAMPT is the cellular target of STF-31-like small-molecule probes.
Adams et al.
ACS Chem.Biol., 2014;9:2247 -
Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells.
Kropp et al.
Stem Cells Transl.Med., 2015;4:483 -
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.
Chan et al.
Sci.Transl.Med., 2011;3:94ra70
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for STF 31
The citations listed below are publications that use Tocris products. Selected citations for STF 31 include:
8 Citations: Showing 1 - 8
-
Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression.
Authors: Lei Et al.
PLoS Genet 2023;19:e1010629
-
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Authors: Fons Et al.
Nat Commun 2019;10:3790
-
Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment.
Authors: Xintaropoulou Et al.
BMC Cancer 2018;18:636
-
Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner.
Authors: Nael A Et al.
Am J Physiol Lung Cell Mol Physiol 2017;312:L688-L702
-
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Authors: Thwe Et al.
Cell Metab 2017;26:558
-
A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models.
Authors: Xintaropoulou Et al.
Oncotarget 2015;6:25677
-
Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells.
Authors: Kropp Et al.
Mol Cell Biol 2015;4:483
-
MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer.
Authors: Robert Et al.
Mol Cancer 2014;13:239
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for STF 31
There are currently no reviews for this product. Be the first to review STF 31 and earn rewards!
Have you used STF 31?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
