SU 11274
Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
Purity: ≥97%
Biological Activity
Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells.
Dai R, Li J, Fu J, Chen Y, Yu L, Zhao X, Qian Y, Zhang H, Chen H, Ren Y, Su B, Luo T, Zhu J, Wang H
J. Biol. Chem., 2012;287(18):14586-97. -
A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
Sattler et al.
Cancer Res., 2003;63:5462 -
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth.
Wang et al.
Mol.Cancer Ther., 2003;2:1085 -
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.
Seiwert et al.
Cancer Res., 2009;69:3021
Product Datasheets
Citations for SU 11274
The citations listed below are publications that use Tocris products. Selected citations for SU 11274 include:
5 Citations: Showing 1 - 5
-
YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells.
Authors: Jiang Et al.
Blood 2015;13:280
-
Differential regulation of c-Met signaling pathways for synovial cell function.
Authors: Shibasaki Et al.
J Transl Med 2014;3:554
-
Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments.
Authors: Boyd Et al.
Tissue Eng Part A 2013;19:211
-
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
Authors: Sullivan Et al.
Springerplus 2012;8:646
-
Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells.
Authors: Dai Et al.
J Biol Chem 2012;287:14586
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for SU 11274
There are currently no reviews for this product. Be the first to review SU 11274 and earn rewards!
Have you used SU 11274?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
