SU 3327
Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Purity: ≥99%
Biological Activity
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
Lo H, Lai T, Li C, Wu W
Acta Pharmacol Sin, 2014;35(3):339-50. -
Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase.
De et al.
J.Med.Chem., 2009;52:1943
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for SU 3327
The citations listed below are publications that use Tocris products. Selected citations for SU 3327 include:
4 Citations: Showing 1 - 4
-
Synergism between the synthetic antibacterial and antibiofilm peptide (SAAP)-148 and halicin.
Authors: van Gent Et al.
Antibiotics (Basel) 2022;11:673
-
Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
Authors: Jang Et al.
J Biol Chem 2015;6:552
-
TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
Authors: Lo Et al.
Acta Pharmacol Sin 2014;35:339
-
Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide.
Authors: Shaw and Lloyd
Redox Biol 2012;84:155
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for SU 3327
There are currently no reviews for this product. Be the first to review SU 3327 and earn rewards!
Have you used SU 3327?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
