SX 011
Chemical Name: 6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide
Purity: ≥98%
Biological Activity
Potent p38α inhibitor (IC50 = 9 nM). Also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Displays no significant activity at p38γ, p38δ, ERK-2 and JNK-1.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein.
Lee and Dominguez
Curr.Med.Chem., 2005;12:2979
Product Datasheets
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