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SZL P1-41

Catalog #: 5076
1 Citation Datasheet / COA / SDS
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SZL P1-41 | CAS No. 222716-34-9 | Ubiquitin Ligase (E3) Inhibitors
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Description: Selective Skp2 inhibitor; suppresses E3 ligase activity

Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Technical Data

M.Wt:
420.52
Formula:
C24H24N2O3S
Solubility:
Soluble to 20 mM in 1eq. HCl and to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
222716-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.
    Chan et al.
    Cell, 2013;154:556
  2. Skp2 modulates proliferation, senescence and tumorigenesis of glioma
    J Wu, HK Su, ZH Yu, SY Xi, CC Guo, ZY Hu, Y Qu, HP Cai, YY Zhao, HF Zhao, FR Chen, YF Huang, ST To, BH Feng, K Sai, ZP Chen, J Wang
    Cancer Cell Int., 2020;20(0):71.

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Citation for SZL P1-41

The citations listed below are publications that use Tocris products. Selected citations for SZL P1-41 include:

1 Citation: Showing 1 - 1

  1. Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling.
    Authors: Jang Et al.
    EMBO J  2017;36:2510

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