TACS Annexin V-FITC Apoptosis Detection Kit Summary
Allows rapid, specific, and quantitative identification of apoptosis in individual cells when using flow cytometry.Why Use the TACS Annexin V-FITC Apoptosis Detection Kit?
Annexin V is a calcium-dependent phospholipid binding protein that can be used to bind Phosphatidylserine(PS) during an early apoptosis event where the PS becomes exposed at the cell surface.
The TACS Annexin V-FITC Apoptosis Detection Kit is supplied with an optimized Binding Buffer and propidium iodide. Propidium iodide may be used on unfixed samples to determine the population of cells that have lost membrane integrity, allowing discrimination between apoptotic and necrotic (or late apoptotic) cells.
Kit Contents
• Annexin V FITC
• 10X Binding Buffer
• Propidium Iodide
Specifications
Limitations
For research use only. Not for diagnostic use.
Product Datasheets
Scientific Data
Detection of Apoptotic Dexamethasone-treated Thymocytes by Annexin V Staining. Thymocytes were left untrated (left) or treated with 100 nM Dexamethasone for 15.5 hours (right) and then stained using Annexin V-FITC and propidium iodide provided in the TACS Annexin V-FITC Apoptosis Detection Kit (Catalog # 4830-250-K). The combination of Annexin V-FITC and propidium iodide allows for the distinction between early apoptotic cells (Annexin V-FITC positive), late apoptotic and/or necrotic cells (Annexin V-FITC and propidium iodide positive), and viable cells (unstained). Analysis courtesy of Dr. C.M. Knudson, Howard Hughes Medical Institute, St. Louis, MO.
Citations for TACS Annexin V-FITC Apoptosis Detection Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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The Effects of Fucoidan Derived from Sargassum filipendula and Fucus vesiculosus on the Survival and Mineralisation of Osteogenic Progenitors
Authors: Gupta, D;Martinez, DC;Puertas-Mejía, MA;Hearnden, VL;Reilly, GC;
International journal of molecular sciences 2024-02-08
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TEAD Inhibition Overcomes YAP1/TAZ-driven Primary and Acquired Resistance to KRASG12C Inhibitors
Authors: Edwards, AC;Stalnecker, CA;Jean Morales, A;Taylor, KE;Klomp, JE;Klomp, JA;Waters, AM;Sudhakar, N;Hallin, J;Tang, TT;Olson, P;Post, L;Christensen, JG;Cox, AD;Der, CJ;
Cancer research 2023-11-07
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Synergistic combination of doxorubicin with hydralazine, and disulfiram against MCF-7 breast cancer cell line
Authors: Lafi, Z;Alshaer, W;Gharaibeh, L;Alqudah, DA;AlQuaissi, B;Bashaireh, B;Ibrahim, AA;
PloS one 2023-09-28
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Krüppel-like Factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and Sphingosine-1-phosphate (S1P) production
Authors: Zhang, CX;Lin, YL;Lu, FF;Yu, NL;Liu, Y;Zhou, JD;Kong, N;Li, D;Yan, GJ;Sun, HX;Cao, GY;
The Journal of biological chemistry 2023-08-03
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Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Authors: Luo, Y;Hao, H;Wang, Z;Ong, C;Dutcher, R;Xu, Y;Liu, J;Pedersen, LC;Xu, D;
bioRxiv : the preprint server for biology 2023-07-26
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Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX
Authors: Singh, R;Yu, S;Osman, M;Inde, Z;Fraser, C;Cleveland, AH;Almanzar, N;Lim, CB;Joshi, GN;Spetz, J;Qin, X;Toprani, SM;Nagel, Z;Hocking, MC;Cormack, RA;Yock, TI;Miller, JW;Yuan, ZM;Gershon, T;Sarosiek, KA;
Cancer research 2023-07-20
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Extracellular vesicles of trypomastigotes of Trypanosoma cruzi induce changes in ubiquitin-related processes, cell-signaling pathways and apoptosis
Authors: Cornet-Gomez, A;Retana Moreira, L;Kronenberger, T;Osuna, A;
Scientific reports 2023-05-10
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Buccal mucosal application of dissolvable microneedle patch containing photosensitizer provides effective localized delivery and phototherapy against oral carcinoma
Authors: R Manimaran, KD Patel, VM Lobo, SS Kumbhar, VVK Venuganti
International journal of pharmaceutics, 2023-04-27;640(0):122991. 2023-04-27
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Nesfatin-1 peptide protects rat renal epithelial cells against high glucose and H2O2 induced injury via inhibition of oxidative stress, apoptosis, and fibrosis
Authors: GP Lahane, A Dhar
Peptides, 2023-04-25;165(0):171013. 2023-04-25
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Anti-Cancer Effects of Oxygen-Atom-Modified Derivatives of Wasabi Components on Human Leukemia Cells
Authors: JF Lin, CW Chi, YC Huang, TH Tsai, YJ Chen
International Journal of Molecular Sciences, 2023-04-06;24(7):. 2023-04-06
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An in vitro investigation of the apoptosis-inducing activity of corosolic acid in breast cancer cells
Authors: SA Jasim, OZ Khalaf, SH Alshahrani, K Hachem, S Ziyadullae, AT Jalil, C Wang, RS Zabibah, YA Bin Jardan, QA Qasim, MS Maashi, YF Mustafa
Iranian journal of basic medical sciences, 2023-04-01;26(4):453-460. 2023-04-01
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SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells
Authors: T Gao, X Yang, M Fujisawa, T Ohara, T Wang, N Tomonobu, M Sakaguchi, T Yoshimura, A Matsukawa
International Journal of Molecular Sciences, 2023-03-05;24(5):. 2023-03-05
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Metallodrugs against Breast Cancer: Combining the Tamoxifen Vector with Platinum(II) and Palladium(II) Complexes
Authors: A Kazimir, B Schwarze, P Lönnecke, S Jela?a, S Mijatovi?, D Maksimovi?, E Hey-Hawkin
Pharmaceutics, 2023-02-17;15(2):. 2023-02-17
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Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial?mesenchymal transition
Authors: H Zhou, X Yun, Y Shu, K Xu
Oncology Letters, 2023-02-01;25(3):101. 2023-02-01
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Nesfatin-1 peptide protects rat renal epithelial cells against high glucose and H2O2 induced injury via inhibition of oxidative stress, apoptosis, and fibrosis
Authors: GP Lahane, A Dhar
Peptides, 2023;165(0):171013. 2023
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NRF2 Regulates Viability, Proliferation, Resistance to Oxidative Stress, and Differentiation of Murine Myoblasts and Muscle Satellite Cells
Authors: I Bronisz-Bu, M Kozakowska, K Pietraszek, M Madej, A Józkowicz, A ?oboda, J Dulak
Cells, 2022-10-21;11(20):. 2022-10-21
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AP39, a Mitochondrial-Targeted H2S Donor, Improves Porcine Islet Survival in Culture
Authors: M Shinzato, C Miyagi-Shi, K Kuwae, K Nishime, Y Tamaki, T Yonaha, M Sakai-Yona, I Yamasaki, R Otsuka, I Saitoh, M Watanabe, H Noguchi
Journal of Clinical Medicine, 2022-09-14;11(18):. 2022-09-14
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Effects of bone morphogenetic protein 4 on TGF-beta1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway
Authors: Z Cai, H Guo, J Qian, W Liu, Y Li, L Yuan, Y Zhou, R Lin, X Xie, Q Yang, G Wu, Q Li, L Zhao, F Liu, J Wang, W Lu
PeerJ, 2022-07-27;10(0):e13775. 2022-07-27
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Magnesium impairs Candida albicans immune evasion by reduced hyphal damage, enhanced beta-glucan exposure and altered vacuole homeostasis
Authors: S Hans, Z Fatima, A Ahmad, S Hameed
PLoS ONE, 2022-07-14;17(7):e0270676. 2022-07-14
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LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression
Authors: J Shi, X Jin, Y Wang, T Zhu, D Zhang, Q Li, X Zhong, Y Deng, J Shen, X Fan
Oncogenesis, 2022-07-02;11(1):37. 2022-07-02
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Berberine regulates PADI4-related macrophage function to prevent lung cancer
Authors: W Gu, M Zhang, F Gao, Y Niu, L Sun, H Xia, W Li, Y Zhang, Z Guo, G Du
Oncogene, 2022-06-25;110(0):108965. 2022-06-25
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Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2
Authors: MK Ko, JI Woo, JM Gonzalez, G Kim, L Sakai, J Peti-Peter, JA Kelber, YK Hong, JC Tan
Oncogene, 2022-06-23;12(1):10623. 2022-06-23
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Transcriptomics-Based Investigation of Molecular Mechanisms Underlying Apoptosis Induced by ZnO Nanoparticles in Human Diffuse Large B-Cell Lymphoma
Authors: SA Alsagaby
International Journal of Nanomedicine, 2022-05-18;17(0):2261-2281. 2022-05-18
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DNA damage alters EGFR signaling and reprograms cellular response via Mre-11
Authors: Y Volman, R Hefetz, E Galun, J Rachmilewi
Scientific Reports, 2022-04-06;12(1):5760. 2022-04-06
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A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect
Authors: TC Ho, SI Yeh, SL Chen, TW Chu, YP Tsao
BMC ophthalmology, 2022-02-22;22(1):88. 2022-02-22
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Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
Authors: AF Mohamed, M Nasr, ME Amer, TMM Abuamara, WM Abd-Elhay, HF Kaabo, EER Matar, LE El Moselhy, TA Gomah, MAE Deban, RI Shebl
Infectious agents and cancer, 2022-02-04;17(1):4. 2022-02-04
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Oxaliplatin delivery via chitosan/vitamin E conjugate micelles for improved efficacy and MDR-reversal in breast cancer
Authors: AM Itoo, M Paul, B Ghosh, S Biswas
Carbohydrate polymers, 2022-01-11;282(0):119108. 2022-01-11
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Drug library screen identifies inhibitors of toxic astrogliosis
Authors: R Masvekar, P Kosa, C Barbour, JL Milstein, B Bielekova
Multiple sclerosis and related disorders, 2022-01-04;58(0):103499. 2022-01-04
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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
Authors: JE Klomp, YS Lee, CM Goodwin, B Papke, JA Klomp, AM Waters, CA Stalnecker, JM DeLiberty, K Drizyte-Mi, R Yang, JN Diehl, HH Yin, M Pierobon, E Baldelli, MB Ryan, S Li, J Peterson, AR Smith, JT Neal, AK McCormick, CJ Kuo, CM Counter, EF Petricoin, AD Cox, KL Bryant, CJ Der
Cell Reports, 2021-11-30;37(9):110060. 2021-11-30
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MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance
Authors: D Mehlich, M ?omiak, A Sobiborowi, A Mazan, D Dymerska, ?M Szewczyk, A Mehlich, A Borowiec, MK Pre?owska, A Gorczy?ski, P Jab?o?ski, E I?ycka-?wi, D Nowis, AA Marusiak
Cell Death & Disease, 2021-11-27;12(12):1111. 2021-11-27
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X-ray repair cross-complementing protein 1 (XRCC1) loss promotes beta-lapachone -induced apoptosis in pancreatic cancer cells
Authors: Y Zheng, H Zhang, Y Guo, Y Chen, H Chen, Y Liu
BMC Cancer, 2021-11-17;21(1):1234. 2021-11-17
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Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis
Authors: GS Lee, G Kwak, JH Bae, JP Han, SH Nam, JH Lee, S Song, GD Kim, TS Park, YK Choi, BO Choi, SC Yeom
Disease Models & Mechanisms, 2021-10-25;14(10):. 2021-10-25
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Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization
Authors: H Lu, X Sun, M Jia, F Sun, J Zhu, X Chen, K Chen, K Jiang
Oxidative Medicine and Cellular Longevity, 2021-10-14;2021(0):5527137. 2021-10-14
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Icariin inhibits epithelial mesenchymal transition of renal tubular epithelial cells via regulating the miR-122-5p/FOXP2 axis in diabetic nephropathy rats
Authors: L Zang, F Gao, A Huang, Y Zhang, Y Luo, L Chen, N Mao
Journal of pharmacological sciences, 2021-10-09;148(2):204-213. 2021-10-09
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Synergistic apoptotic effect of miR-183-5p and Polo-Like kinase 1 inhibitor NMS-P937 in breast cancer cells
Authors: M Kudo, N Zalles, R Distefano, G Nigita, D Veneziano, P Gasparini, CM Croce
Cell Death and Differentiation, 2021-09-24;0(0):. 2021-09-24
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A novel miRNA-762/NFIX pathway modulates LPS-induced acute lung injury
Authors: XL Zhang, J An, YZ Deng, XZ Fang, CY Xu, XF Liu, ZH Bai, G Zhang, MY Cui
International immunopharmacology, 2021-09-04;100(0):108066. 2021-09-04
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Inhibition of lipid metabolism exerts antitumor effects on rhabdomyosarcoma
Authors: S Miyagaki, K Kikuchi, J Mori, GD Lopaschuk, T Iehara, H Hosoi
Cancer Medicine, 2021-09-02;10(18):6442-6455. 2021-09-02
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Mechanistic insights into the antimycobacterial action of unani formulation, Qurs Sartan Kafoori
Authors: S Hameed, S Hans, S Nandan, Z Fatima
Journal of traditional and complementary medicine, 2021-07-30;12(2):162-171. 2021-07-30
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Au2phen and Auoxo6, Two Dinuclear Oxo-Bridged Gold(III) Compounds, Induce Apoptotic Signaling in Human Ovarian A2780 Cancer Cells
Authors: G Gorini, F Magherini, T Fiaschi, L Massai, M Becatti, A Modesti, L Messori, T Gamberi
Biomedicines, 2021-07-23;9(8):. 2021-07-23
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
Authors: AM Waters, TO Khatib, B Papke, CM Goodwin, GA Hobbs, JN Diehl, R Yang, AC Edwards, KH Walsh, R Sulahian, JM McFarland, KS Kapner, TSK Gilbert, CA Stalnecker, S Javaid, A Barkovskay, KR Grover, PS Hibshman, DR Blake, A Schaefer, KM Nowak, JE Klomp, TK Hayes, M Kassner, N Tang, O Tanaseichu, K Chen, Y Zhou, M Kalkat, LE Herring, LM Graves, LZ Penn, HH Yin, AJ Aguirre, WC Hahn, AD Cox, CJ Der
Cell Reports, 2021-06-29;35(13):109291. 2021-06-29
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Polymer Coated Oncolytic Adenovirus to Selectively Target Hepatocellular Carcinoma Cells
Authors: M Garofalo, F Bellato, S Magliocca, A Malfanti, L Kuryk, B Rinner, S Negro, S Salmaso, P Caliceti, F Mastrotto
Pharmaceutics, 2021-06-24;13(7):. 2021-06-24
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Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells
Authors: S Funakoshi, I Fernandes, O Mastikhina, D Wilkinson, T Tran, W Dhahri, A Mazine, D Yang, B Burnett, J Lee, S Protze, GD Bader, SS Nunes, M Laflamme, G Keller
Nature Communications, 2021-05-26;12(1):3155. 2021-05-26
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The Effects of Muscle Cell Aging on Myogenesis
Authors: A Moustogian, A Philippou, O Taso, E Zevolis, M Pappa, A Chatzigeor, M Koutsilier
International Journal of Molecular Sciences, 2021-04-02;22(7):. 2021-04-02
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LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma
Authors: X Hou, X Shi, W Zhang, D Li, L Hu, J Yang, J Zhao, S Wei, X Wei, X Ruan, X Zheng, M Gao
Cell Death & Disease, 2021-04-01;12(4):347. 2021-04-01
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Synthesis and Biological Evaluation of Novel Isoxazole-Amide Analogues as Anticancer and Antioxidant Agents
Authors: AM Eid, M Hawash, J Amer, A Jarrar, S Qadri, I Alnimer, A Sharaf, R Zalmoot, O Hammoudie, S Hameedi, A Mousa
BioMed Research International, 2021-03-09;2021(0):6633297. 2021-03-09
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In vivo fermentation production of humanized noncoding RNAs carrying payload miRNAs for targeted anticancer therapy
Authors: PC Li, MJ Tu, PY Ho, N Batra, MML Tran, JX Qiu, T Wun, PN Lara, X Hu, AX Yu, AM Yu
Theranostics, 2021-03-04;11(10):4858-4871. 2021-03-04
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
Authors: P Nylund, A Atienza Pá, J Haglöf, E De Bruyne, E Menu, B Garrido-Za, A Ma, J Jin, F Öberg, K Vanderkerk, A Kalushkova, H Jernberg-W
Cell Death & Disease, 2021-02-12;12(2):167. 2021-02-12
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Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing
Authors: JY Lee, DJ Min, W Kim, BH Bin, K Kim, EG Cho
Scientific Reports, 2021-01-28;11(1):2465. 2021-01-28
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Superior Effect of the Combination of Carbon-Ion Beam Irradiation and 5-Fluorouracil on Colorectal Cancer Stem Cells in vitro and in vivo
Authors: WS Koom, S Sai, M Suzuki, A Fujimori, S Yamada, H Tsujii
OncoTargets and Therapy, 2020-12-08;13(0):12625-12635. 2020-12-08
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Evaluation of immunomodulatory effects of Boswellia sacra essential oil on T-cells and dendritic cells
Authors: AM Aldahlawi, AT Alzahrani, MF Elshal
BMC Complement Med Ther, 2020-11-19;20(1):352. 2020-11-19
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Sensitivity of Papilloma Virus-Associated Cell Lines to Photodynamic Therapy with Curcumin-Loaded Liposomes
Authors: G Ambreen, L Duse, I Tariq, U Ali, S Ali, SR Pinnapired, M Bette, U Bakowsky, R Mandic
Cancers (Basel), 2020-11-05;12(11):. 2020-11-05
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Indole-6-Carboxaldehyde Isolated from Sargassum thunbergii (Mertens) Kuntze Prevents Oxidative Stress-Induced Cellular Damage in V79-4 Chinese Hamster Lung Fibroblasts through the Activation of the Nrf2/HO-1 Signaling Pathway
Authors: SO Kim, YH Choi
Cell Physiol Biochem, 2020-10-01;54(5):959-974. 2020-10-01
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Exosomal lncRNA H19 promotes the progression of hepatocellular carcinoma treated with Propofol via miR-520a-3p/LIMK1 axis
Authors: D Wang, N Xing, T Yang, J Liu, H Zhao, J He, Y Ai, J Yang
Cancer Med, 2020-08-07;0(0):. 2020-08-07
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Protein tyrosine phosphatase 1B as a therapeutic target for Graves' orbitopathy in an in vitro model
Authors: HJ Byeon, JY Kim, J Ko, EJ Lee, K Don, JS Yoon
PLoS ONE, 2020-08-06;15(8):e0237015. 2020-08-06
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Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway
Authors: C Park, H Lee, JS Noh, CY Jin, GY Kim, JW Hyun, SH Leem, YH Choi
Arch. Biochem. Biophys., 2020-07-24;691(0):108512. 2020-07-24
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Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition
Authors: AR Paliouras, M Buzzetti, L Shi, IJ Donaldson, P Magee, S Sahoo, HS Leong, M Fassan, M Carter, G Di Leva, MG Krebs, F Blackhall, CM Lovly, M Garofalo
EMBO Mol Med, 2020-06-17;0(0):e11099. 2020-06-17
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
Authors: I Ozkan-Dagl, JN Diehl, SD George, A Schaefer, B Papke, K Klotz-Noac, AM Waters, CM Goodwin, P Gautam, M Pierobon, S Peng, TSK Gilbert, KH Lin, O Dagliyan, K Wennerberg, EF Petricoin, NL Tran, SV Bhagwat, RV Tiu, SB Peng, LE Herring, LM Graves, C Sers, KC Wood, AD Cox, CJ Der
Cell Rep, 2020-06-16;31(11):107764. 2020-06-16
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Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells
Authors: Y Tatsumi, M Miyake, K Shimada, T Fujii, S Hori, Y Morizawa, Y Nakai, S Anai, N Tanaka, N Konishi, K Fujimoto
Int J Mol Sci, 2020-05-27;21(11):. 2020-05-27
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Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts
Authors: CA Nadalutti, DF Stefanick, ML Zhao, JK Horton, R Prasad, AM Brooks, JD Griffith, SH Wilson
Sci Rep, 2020-03-27;10(1):5575. 2020-03-27
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IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer
Authors: T Manabe, H Yasuda, H Terai, H Kagiwada, J Hamamoto, T Ebisudani, K Kobayashi, K Masuzawa, S Ikemura, I Kawada, Y Hayashi, K Fukui, K Horimoto, K Fukunaga, K Soejima
Mol. Cancer Res., 2020-01-15;0(0):. 2020-01-15
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Apatinib ameliorates doxorubicin-induced migration and cancer stemness of osteosarcoma cells by inhibiting Sox2 via STAT3 signalling
Authors: ZC Tian, JQ Wang, H Ge
J Orthop Translat, 2019-08-07;22(0):132-141. 2019-08-07
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Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells
Authors: A P, A K, S L, M M, M K
Toxicol Rep, 2019-06-15;6(0):556-563. 2019-06-15
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Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response
Authors: H Schwenzer, F Jühling, A Chu, LJ Pallett, TF Baumert, M Maini, A Fassati
Cell Rep, 2019-03-19;26(12):3416-3428.e5. 2019-03-19
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Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis
Authors: KK Kim, MR Dotson, M Agarwal, J Yang, PB Bradley, N Subbotina, JJ Osterholze, TH Sisson
Cell Death Dis, 2018-10-17;9(11):1056. 2018-10-17
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CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure.
Authors: Kuse Y, Tsuruma K, Kanno Y, Shimazawa M, Hara H
Front Pharmacol, 2017-04-18;8(0):207. 2017-04-18
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EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells
Authors: H Takada, KI Imadome, H Shibayama, M Yoshimori, L Wang, Y Saitoh, S Uota, S Yamaoka, T Koyama, N Shimizu, K Yamamoto, S Fujiwara, O Miura, A Arai
PLoS ONE, 2017-03-27;12(3):e0174136. 2017-03-27
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Endothelial Cells Inhibit the Angiotensin II Induced Phenotypic Modulation of Rat Vascular Adventitial Fibroblasts.
Authors: Xu J, Chang N, Li T, Jiang R, Sun X, He Y, Jiang J
J Cell Biochem, 2017-03-24;118(7):1921-1927. 2017-03-24
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Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
Authors: MJ Mitchell, J Webster, A Chung, PP Guimarães, OF Khan, R Langer
Nat Commun, 2017-03-20;8(0):14179. 2017-03-20
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Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.
Authors: McGrath J, Williamson K, Balasubramanian S, Odate S, Arora S, Hatton C, Edwards T, O'Brien T, Magnuson S, Stokoe D, Daniels D, Bryant B, Trojer P
Cancer Res, 2016-02-02;76(7):1975-88. 2016-02-02
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Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.
Authors: Uttarkar S, Dasse E, Coulibaly A, Steinmann S, Jakobs A, Schomburg C, Trentmann A, Jose J, Schlenke P, Berdel W, Schmidt T, Muller-Tidow C, Frampton J, Klempnauer K
Blood, 2015-12-02;127(9):1173-82. 2015-12-02
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Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system.
Authors: Keshwani M, Kanter J, Ma Y, Wilderman A, Darshi M, Insel P, Taylor S
Proc Natl Acad Sci U S A, 2015-09-28;112(41):12681-6. 2015-09-28
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Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity.
Authors: Balasubramanian K, Maeda A, Lee J, Mohammadyani D, Dar H, Jiang J, St Croix C, Watkins S, Tyurin V, Tyurina Y, Kloditz K, Polimova A, Kapralova V, Xiong Z, Ray P, Klein-Seetharaman J, Mallampalli R, Bayir H, Fadeel B, Kagan V
Sci Signal, 2015-09-22;8(395):ra95. 2015-09-22
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Kruppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling.
Authors: Brown A, Simmen R, Raj V, Van T, MacLeod S, Simmen F
Carcinogenesis, 2015-07-25;36(9):946-55. 2015-07-25
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MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.
Authors: Joshi P, Jeon Y, Lagana A, Middleton J, Secchiero P, Garofalo M, Croce C
Proc Natl Acad Sci U S A, 2015-06-29;112(28):8650-5. 2015-06-29
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A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications.
Authors: Chen Q, Wang W, Zeng S, Urayama S, Yu A
Nucleic Acids Res, 2015-03-23;43(7):3857-69. 2015-03-23
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Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300.
Authors: Uttarkar S, Dukare S, Bopp B, Goblirsch M, Jose J, Klempnauer K
Mol Cancer Ther, 2015-03-04;14(6):1276-85. 2015-03-04
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An LRP16-containing preassembly complex contributes to NF-kappaB activation induced by DNA double-strand breaks.
Authors: Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, Wang Y, Fu X, Luo G, Han W
Nucleic Acids Res, 2015-03-03;43(6):3167-79. 2015-03-03
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PCK3145 inhibits proliferation and induces apoptosis in breast and colon cancer cells.
Authors: Kostopoulos A, Papageorgiou E, Koutsilieris M, Sivolapenko G
Anticancer Res, 2015-03-01;35(3):1377-84. 2015-03-01
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Staphylococcus aureus Inhibits Neutrophil-derived IL-8 to Promote Cell Death.
Authors: Zurek O, Pallister K, Voyich J
J Infect Dis, 2015-02-26;212(6):934-8. 2015-02-26
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The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2.
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Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure.
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