TBB
Chemical Name: 4,5,6,7-Tetrabromobenzotriazole
Purity: ≥98%
Biological Activity
TBB is a cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process.
Melhorn M, Brodsky A, Estanislau J, Khoory J, Illigens B, Hamachi I, Kurishita Y, Fraser A, Nicholson-Weller A, Dolmatova E, Duffy H, Ghiran I
J Biol Chem, 2013;288(43):31139-53. -
Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
Sarno et al.
FEBS Lett., 2001;496:44 -
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Pagano et al.
J.Med.Chem., 2004;47:6239 -
Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
Zien et al.
Biochim.Biophys.Acta., 2005;1754:271
Product Datasheets
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Citations for TBB
The citations listed below are publications that use Tocris products. Selected citations for TBB include:
6 Citations: Showing 1 - 6
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M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment.
Authors: Lezmy
Proc Natl Acad Sci U S A 2017;114(47):E10234
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Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.
Authors: Bartley Et al.
Eneuro 2016;3
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Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages.
Authors: Navasa Et al.
J Urol 2015;5:14692
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BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
Authors: Korb Et al.
Sci Rep 2015;18:1464
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The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.
Authors: Wu Et al.
Autophagy 2014;10:1712
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Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Authors: Buchanan Et al.
Neuron 2010;68:948
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