TC 1698 dihydrochloride
Discontinued Product
Chemical Name: 2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride
Purity: ≥98%
Biological Activity
TC 1698 dihydrochloride is a selective nicotinic α7 receptor agonist (EC50 = 440 nM). Also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Neuroprotective.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase.
Marrero et al.
J.Pharmacol.Exp.Ther., 2004;309:16 -
Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes.
Papke et al.
Eur.J.Pharmacol., 2005;524:11
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