Home / Aurora Kinase Inhibitors / TC-A 2317 hydrochloride

TC-A 2317 hydrochloride

Catalog #: 4066
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4066/10
4066/50
TC-A 2317 hydrochloride | CAS No. 1245907-03-2 | Aurora Kinase Inhibitors
1 Image
Description: Potent, selective Aurora kinase A inhibitor

Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-A 2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Technical Data

M.Wt:
392.93
Formula:
C19H28N6O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1245907-03-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors.
    Ando et al.
    Bioorg.Med.Chem.Lett., 2010;20:4709

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for TC-A 2317 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for TC-A 2317 hydrochloride include:

3 Citations: Showing 1 - 3

  1. EGFR-Aurka signaling rescues polarity and regeneration defects in dystrophin-deficient muscle stem cells by increasing asymmetric divisions.
    Authors: Wang Et al.
    Cell Stem Cell  2019;24:419
  2. Kinase-controlled phase transition of membraneless organelles in mitosis.
    Authors: Lucas Et al.
    Nature  2018;559:211-216
  3. The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.
    Authors: Min Et al.
    Oncotarget  2016;7:84718

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TC-A 2317 hydrochloride

There are currently no reviews for this product. Be the first to review TC-A 2317 hydrochloride and earn rewards!

Have you used TC-A 2317 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.