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TC-E 5002

Catalog #: 5089
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5089/10
5089/50
TC-E 5002 | CAS No. 1453071-47-0 | Histone Demethylase Inhibitors
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Description: Selective KDM2/7 inhibitor

Chemical Name: N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

Technical Data

M.Wt:
285.38
Formula:
C15H27NO4
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1453071-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for TC-E 5002

The citations listed below are publications that use Tocris products. Selected citations for TC-E 5002 include:

1 Citation: Showing 1 - 1

  1. NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
    Authors: David E Et al.
    Mol Cell  2022;82:2472-2489.e8

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