TC-FPR 43
Chemical Name: N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
Purity: ≥98%
Biological Activity
TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
Dufton et al.
J.Immunol., 2010;184:2611 -
Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.
Bürli et al.
Bioorg.Med.Chem.Lett., 2006;16:3713 -
Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library.
Forsman et al.
Biochem.Pharmacol., 2011;81:402
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