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TC NTR1 17

Catalog #: 5087 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5087/10
5087/50
TC NTR1 17 | CAS No. 1146757-96-1 | Neurotensin Receptor Agonists
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Description: Selective NTS1 partial agonist
Alternative Names: ML 301 analog

Chemical Name: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine

Purity: ≥99%

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Biological Activity

TC NTR1 17 is a non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.

Technical Data

M.Wt:
522.98
Formula:
C27H27ClN4O5
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1146757-96-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Imidazole-derived agonists for the neurotensin 1 receptor.
    Hershberger et al.
    Bioorg.Med.Chem.Lett., 2014;24:262

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