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TC-S 7005

Catalog #: 4459
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TC-S 7005 | CAS No. 1082739-92-1 | Polo-like Kinase Inhibitors
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Description: Potent and selective PLK2 inhibitor

Chemical Name: 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Technical Data

M.Wt:
359.38
Formula:
C21H17N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1082739-92-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
    Hanan et al.
    Bioorg.Med.Chem.Lett., 2008;18:5186

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Citation for TC-S 7005

The citations listed below are publications that use Tocris products. Selected citations for TC-S 7005 include:

1 Citation: Showing 1 - 1

  1. Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
    Authors: Arimoto Et al.
    Nat Commun  2023;14:251

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