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TCB-2

Catalog #: 2592
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2592/10
2592/50
TCB-2 | CAS No. 912342-28-0 | 5-HT2A Receptor Agonists
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Description: High affinity and potent 5-HT2A agonist

Chemical Name: (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide

Purity: ≥99%

Product Details
Citations (9)
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Biological Activity

TCB-2 is a high affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. administration.

Technical Data

M.Wt:
353.05
Formula:
C11H14BrNO2.HBr
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
912342-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCB-2

The citations listed below are publications that use Tocris products. Selected citations for TCB-2 include:

9 Citations: Showing 1 - 9

  1. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.
    Authors: Kawai Et al.
    Nat.Commun.  2022;13:7708
  2. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
    Authors: Nagata Et al.
    Sci Rep  2019;9:16438
  3. Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease.
    Authors: Afshar Et al.
    J.Chem.Neuroanat.  2019;96:140
  4. Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
    Authors: Hooper Et al.
    Am J Physiol Heart Circ Physiol  2016;311:H572
  5. The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model.
    Authors: Dong Et al.
    Exp Ther Med  2016;12:3583
  6. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    PLoS One  2015;3:e00103
  7. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  8. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
    Authors: Goda Et al.
    Psychopharmacology (Berl)  2013;228:271
  9. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
    Authors: Niebert Et al.
    EMBO Mol Med  2011;6:e21395

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