TCID
Discontinued Product
5179 has been discontinued.
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Description: Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Purity: ≥99%
Biological Activity
TCID is a selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.Technical Data
M.Wt:
283.92
Formula:
C9H2Cl4O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
30675-13-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Liu et al.
Chem.Biol., 2003;10:837 -
Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.
de Juan-Sanz et al.
PLoS ONE, 2013;8:e58863
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