TCN 201

Catalog #: 4154
14 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4154/10
4154/50

TCN 201 | CAS No. 852918-02-6 | NMDA Receptor Antagonists

1 Image

Description: GluN1/GluN2A-selective NMDA antagonist

Chemical Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide

Purity: ≥99%

View All Products for NMDA Receptor Antagonists

Product Details

Citations (14)

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TCN 201 is a NMDA receptor antagonist selective for GluN1/GluN2A (formally NR1/NR2A) over GluN1/GluN2B (formally NR1/NR2B) containing receptors (pIC₅₀ values are 6.8 and <4.3, respectively, in human recombinant GluN1/GluN2A (formally NR1/NR2A) and GluN1/GluN2B (formally NR1/NR2B) FLIPR/Ca²⁺ assays).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:

461.89

Formula:

C₂₁H₁₇ClFN₃O₄S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

852918-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing

Cell Rep, 2016;17(10):2753-2765.
Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.
Shin et al.
Br.J.Pharmacol., 2011;166:1002
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Edman et al.
Neuropharmacology, 2012;63:441
Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.
Hansen et al.
J.Neurosci., 2012;32:6197
Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.
Gipson et al.
Proc.Natl.Acad.Sci.U S A [Epub ahead of print], 2013;
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Bettini et al.
J.Pharm.Exp.Ther., 2010;335:644
Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling
G Chen, J Xu, H Luo, X Luo, SK Singh, JJ Ramirez, ML James, JP Mathew, M Berger, C Eroglu, RR Ji
JCI Insight, 2022;7(23):.

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for TCN 201

The citations listed below are publications that use Tocris products. Selected citations for TCN 201 include:

14 Citations: Showing 1 - 10

Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.
Authors: Gang Et al.
JCI Insight 2022;7
GluN2B but Not GluN2A for Basal Dendritic Growth of Cortical Pyramidal Neurons.
Authors: Petra Et al.
Front Neuroanat 2020;14:571351
HIV gp120-induced neuroinflammation potentiates NMDA receptors to overcome basal suppression of inhibitory synapses by p38 MAPK.
Authors: Xinwen Et al.
J Neurochem 2019;148:499-515
Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
Authors: Lassus Et al.
Sci Rep 2018;8:17461
Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Authors: Brancaccio Et al.
Neuron 2017;93:1420
β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.
Authors: Chen Et al.
Nature Communications 2016;7:12531
STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
Authors: Tian Et al.
Scientific Reports 2016;6:36684
NR2A contributes to genesis and propagation of cortical spreading depression in rats.
Authors: Bu Et al.
Sci Rep 2016;6:23576
NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
Authors: McQuail Et al.
J Neurosci 2016;36:12537
The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood.
Authors: Liu Et al.
Mol Brain 2015;8:49

miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
Authors: Gu Et al.
Nat Commun 2015;6:6789

Sensitivity of N-MthD.-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
Authors: Izumi and Zorumski
PeerJ 2015;352:267

miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1.
Authors: Hu Et al.
J Pharmacol Exp Ther 2015;208:949

Age-dependent regulation of synaptic connections by DA D2 receptors.
Authors: Jia Et al.
Nat Neurosci 2013;16:1627

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TCN 201

There are currently no reviews for this product. Be the first to review TCN 201 and earn rewards!

Have you used TCN 201?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.