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TCS PIM-1 4a

Catalog #: 3714 Datasheet / COA / SDS

Discontinued Product

3714 has been discontinued.
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TCS PIM-1 4a | CAS No. 438190-29-5 | Pim Kinase Inhibitors
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Description: Selective, ATP-competitive Pim kinase inhibitor
Alternative Names: SMI-4a

Chemical Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

Purity: ≥98%

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Biological Activity

Selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).

Technical Data

M.Wt:
273.23
Formula:
C11H6F3NO2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
438190-29-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
    Xia et al.
    J.Med.Chem., 2009;52:74

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