Telenzepine dihydrochloride
Chemical Name: 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
Purity: ≥98%
Biological Activity
Telenzepine dihydrochloride is a selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Inhibits gastric acid secretion.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine.
Christofi et al.
Eur.J.Pharmacol., 1991;195:333 -
Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug.
Eltze et al.
Eur.J.Pharmacol., 1985;112:211 -
Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia.
Galvan et al.
Eur.J.Pharmacol., 1989;167:1
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Citation for Telenzepine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Telenzepine dihydrochloride include:
1 Citation: Showing 1 - 1
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Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs.
Authors: Pediani Et al.
J.Biol.Chem. 2016;291:13132
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