Telmisartan
Discontinued Product
Chemical Name: 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid
Purity: ≥99%
Biological Activity
Telmisartan is an antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An adipose tissue-independent Ins-sensitizing action of telmisartan: a study in lipodystrophic mice.
Rong et al.
J.Pharmacol.Exp.Ther., 2009;331:1096 -
6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.
Ries et al.
J.Med.Chem., 1993;36:4040 -
Identification of telmis. as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity.
Benson et al.
Hypertension, 2004;43:993
Product Datasheets
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Citations for Telmisartan
The citations listed below are publications that use Tocris products. Selected citations for Telmisartan include:
2 Citations: Showing 1 - 2
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Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response.
Authors: Josef M Et al.
Cell Mol Life Sci 2018;75:3625-3634
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Development of telmis. in the therapy of spinal cord injury: pre-clinical study in rats.
Authors: Lin Et al.
Psychopharmacology (Berl) 2015;9:4709
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