TFLLR-NH2
Purity: ≥95%
Biological Activity
TFLLR-NH2 is a peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo.Control Peptide also available.
Technical Data
(Modification: Arg-5 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Tissue factor and glycoprotein C on herpes simplex virus type 1 are protease-activated receptor 2 cofactors that enhance infection.
Sutherland MR, Ruf W, Pryzdial EL
Blood, 2012;119(15):3638-45. -
Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin
C Zalfa, P Azmoon, E Mantuano, SL Gonias
J. Leukoc. Biol., 2019;0(0):. -
Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response.
Battinelli, Elisabet, Markens, Beth A, Kulenthirarajan, Rajesh A, Machlus, Kellie R, Flaumenhaft, Robert, Italiano, Joseph E
Blood, 2014;123(1):101-12. -
Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides.
Hollenberg et al.
Can.J.Physiol.Pharmacol., 1997;75:832 -
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism.
de Garavilla et al.
Br.J.Pharmacol., 2001;133:975 -
Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.
Kawabata et al.
Life Sci., 2000;67:2521
Product Datasheets
Reconstitution Calculator
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Citations for TFLLR-NH2
The citations listed below are publications that use Tocris products. Selected citations for TFLLR-NH2 include:
11 Citations: Showing 1 - 10
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Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing.
Authors: Zhang Et al.
J Tissue Eng 2019;10:2041731418820030
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Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β.
Authors: M?ller Et al.
Curr Biol 2018;28:3481
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PAR1?mediated c?Jun activation promotes heat stress?induced early stage apoptosis of human umbilical vein endothelial cells.
Authors: Zhang Et al.
Mol Med Rep 2017;15:2595
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Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.
Authors: Wang
Proc Natl Acad Sci U S A 2017;114(41):10948
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Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
Authors: Carlsen and Perrier
Front Neural Circuits 2014;8:60
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Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation.
Authors: Chen Et al.
Endocrinology 2012;9:142
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Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
Authors: Wang Et al.
J Neuroinflammation 2012;5:ra26
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Thrombin activity associated with neuronal damage during acute focal ischemia.
Authors: Chen Et al.
J Neurosci 2012;32:7622
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An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
Authors: Gómez-Gonzalo Et al.
PLoS Biol 2010;8:e1000352
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Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
Authors: Vellani Et al.
Mol Pain 2010;6:61
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The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion.
Authors: Fujimoto Et al.
BMC Cancer 2010;10:443
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Effect of TFLLR-NH2 on PLCbeta activity in HASMCs
5uM TFLLR-NH2 was treated on platelets and the TGFb1 release was measured by ELISA.
