TG 003
Chemical Name: (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98%
Biological Activity
TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Manipulation of alternative splicing by a newly developed inhibitor of Clks.
Muraki et al.
J.Biol.Chem., 2004;279:24246 -
Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.
Foucourt et al.
Molecules, 2014;19:15411
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Citation for TG 003
The citations listed below are publications that use Tocris products. Selected citations for TG 003 include:
1 Citation: Showing 1 - 1
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Kinase-controlled phase transition of membraneless organelles in mitosis.
Authors: Lucas Et al.
Nature 2018;559:211-216
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