TGN 020
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Purity: ≥98%
Biological Activity
TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of aquaporin 4 inhibitors using in vitro and in silico methods.
Huber et al.
Bioorg.Med.Chem., 2009;17:411 -
Inhibition of aquaporin-4 significantly increases regional cerebral blood flow.
Igarashi et al.
Neuroreport, 2013;24:324 -
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.
Igarashi and Huber
Neurol.Sci., 2011;32:113 -
Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/&beta-Catenin Signaling
Y Li, M Chen, J Hu, R Sheng, Q Lin, X He, M Guo
Cell Stem Cell, 2020;0(0):.
Product Datasheets
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Citations for TGN 020
The citations listed below are publications that use Tocris products. Selected citations for TGN 020 include:
2 Citations: Showing 1 - 2
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Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.
Authors: Harrison Et al.
Brain 2020;143:2576
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Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1.
Authors: Wang Et al.
J Biol Chem 2017;292:8291
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