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TH 9619 disodium salt

Catalog #: 7719 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7719/50
7719/10
TH 9619 disodium salt | Dehydrogenase Inhibitors
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Description: MTHFD2 inhibitor

Chemical Name: Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate

Purity: ≥98%

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Biological Activity

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AML) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AML.

Technical Data

M.Wt:
495.33
Formula:
C17H16FN7Na2O7
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Thomas Helleday's Foundation for Medical Research and One-Carbon Therapeutics

Product Datasheets

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