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Thalidomide 4'-ether-alkylC6-amine

Catalog #: 6627 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6627/25
Thalidomide 4'-ether-alkylC6-amine | CAS No. 2245697-88-3 | Degrader Building Blocks
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Description: Cereblon ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names: Thalidomide - linker 4

Chemical Name: 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride

Purity: ≥95%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Thalidomide 4'-ether-alkylC6-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a C6 alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 4

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
409.86
Formula:
C19H23N3O5.HCl
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2245697-88-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The dTAG system for immediate and target-specific protein degradation.
    Nabet et al.
    Nat.Chem.Biol., 2018;14:431
  2. Transcription control by the ENL YEATS domain in acute leukaemia.
    Erb et al.
    Nature., 2017;543:270

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protacs
By Sandipan Roy Chowdhury on 05/20/2020
Species: cells

to make protacs

protacs 6627
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