Home / Degrader Building Blocks / Thalidomide 4'-ether-PEG2-alkyne

Thalidomide 4'-ether-PEG2-alkyne

Catalog #: 6686 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6686/25
Thalidomide 4'-ether-PEG2-alkyne | CAS No. 2098487-52-4 | Degrader Building Blocks
1 Image
Description: Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
Alternative Names: Thalidomide - linker 5

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione

Purity: ≥95%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 5

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
400.38
Formula:
C20H20N2O7
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2098487-52-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Degradation of the BAF complex factor BRD9 by heterobifunctional ligands.
    Remillard et al.
    Angew.Chem.Int.Ed.Engl., 2017;56:5738

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Thalidomide 4'-ether-PEG2-alkyne

There are currently no reviews for this product. Be the first to review Thalidomide 4'-ether-PEG2-alkyne and earn rewards!

Have you used Thalidomide 4'-ether-PEG2-alkyne?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.