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Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Catalog #: 6913 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6913/25
Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine | CAS No. 2564466-93-7 | Degrader Building Blocks
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Description: Cereblon ligand with alkyl-PEG-alkyl linker and terminal amine for onward chemistry

Chemical Name: N-[3-[2-[2-(3-Aminopropoxy)ethoxy]ethoxy]propyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride

Purity: ≥95%

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Biological Activity

Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC1-PEG3-alkylC3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
571.02
Formula:
C25H34N4O9.HCl
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2564466-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The dTAG system for immediate and target specific protein degradation.
    Nabet et al.
    Nat.Chem.Biol., 2018;14:431

Product Datasheets

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