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Thalidomide, 5'-fluoro

Catalog #: 7456 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7456/100
Thalidomide, 5'-fluoro | CAS No. 835616-61-0 | Degrader Building Blocks
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Description: Fluoro functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione

Purity: ≥95%

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Biological Activity

Thalidomide 5'- fluoro is a derivative of Thalidomide (Cat. No. 0652), commonly used as a precursor to PROTAC® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
276.22
Formula:
C13H9FN2O4
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
835616-61-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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