THDOC
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Description: Positive modulator of GABAA receptors; endogenous neurosteroid
Chemical Name: (3α,5α)-3,21-Dihydroxypregnan-20-one
Purity: ≥95%
Biological Activity
THDOC is a positive modulator of GABAA receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. Endogenous neurosteroid.Technical Data
M.Wt:
334.49
Formula:
C21H34O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at RT
CAS No:
567-02-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.
Villumsen et al.
BMC.Neurosci., 2015;16 -
Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors.
Adams et al.
Neuropharmacology., 2015;88:63
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