Tiotidine

Catalog #: 0826
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0826/10
0826/50

Tiotidine | CAS No. 69014-14-8 | Histamine H2 Receptor Antagonists

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Description: Potent and selective H2 antagonist

Alternative Names: ICI 125,211

Purity: ≥98%

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Product Details

Citations (5)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Tiotidine is a potent histamine H₂-receptor antagonist with negligible activity against H₁- and H₃- receptors.

Technical Data

M.Wt:

312.41

Formula:

C₁₀H₁₆N₈S₂

Solubility:

Soluble to 10 mM in ethanol and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

69014-14-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of AstraZeneca UK Ltd.

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Distribution, properties, and functional characteristics of three classes of histamine receptor.
Hill et al.
Pharmacol.Rev., 1990;42:45
The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H₂- receptor antagonist.
Trzeciakowski and Levi
J.Pharmacol.Exp.Ther., 1980;214:629
ICI 125,211: A new gastric antisecretory agent acting on histamine H₂- receptors.
Yellin et al.
Life Sci., 1979;25:2001

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Tiotidine

The citations listed below are publications that use Tocris products. Selected citations for Tiotidine include:

5 Citations: Showing 1 - 5

Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
Physiological implications of biased signaling at histamine H2 receptors.
Authors: Alonso Et al.
Exp Ther Med 2015;6:45
Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.
Authors: Chigaev Et al.
J Biol Chem 2011;286:20375
Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
Authors: Holden Et al.
Front Pharmacol 2007;152:891
Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
Authors: Flamand Et al.
Br J Pharmacol 2004;141:552

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