Tiplaxtinin
Chemical Name: α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
Purity: ≥98%
Biological Activity
Tiplaxtinin is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.
Elokdah et al.
J.Med.Chem., 2004;47:3491 -
A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage.
Simone et al.
Cell.Signal., 2015;27:923
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Citation for Tiplaxtinin
The citations listed below are publications that use Tocris products. Selected citations for Tiplaxtinin include:
1 Citation: Showing 1 - 1
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ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.
Authors: Zhang Et al.
Sci Adv 2020;6
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