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TL 12-186

Catalog #: 6524 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6524/5
TL 12-186 | CAS No. 2250025-88-6 | Active Degraders
1 Image
Description: Multikinase Degrader (PROTAC®)

Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

Purity: ≥98%

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Biological Activity

TL 12-186 is a degrader (PROTAC®) comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines.

Negative control TL 13-27 (Cat. No. 6525) is also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
931.46
Formula:
C44H51ClN10O9S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2250025-88-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader.
    Huang et al.
    Cell Chem.Biol., 2018;25:88

Product Datasheets

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