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TL 13-12

Catalog #: 6744
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6744/5
TL 13-12 | CAS No. 2229037-04-9 | Active Degraders
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Description: Selective ALK Degrader (PROTAC®)

Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat. No. 6745). Maximum degradation is exhibited at 16 h.

Negative control TL 13-22 (Cat. No. 6747) and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
961.48
Formula:
C45H53ClN10O10S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2229037-04-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Chemically induced degradation of anaplastic lymphoma kinase (ALK).
    Powell et al.
    J.Med.Chem., 2019;61:4249

Product Datasheets

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Citation for TL 13-12

The citations listed below are publications that use Tocris products. Selected citations for TL 13-12 include:

1 Citation: Showing 1 - 1

  1. Engineered PROTAC-CID systems for mammalian inducible gene regulation
    Authors: Ma Et al.
    J Am Chem Soc  2023;145:1593

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