TMPyP4 tosylate

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461
   G Li, J Shen, J Cao, G Zhou, T Lei, Y Sun, H Gao, Y Ding, W Xu, Z Zhan, Y Chen, H Huang
   J. Exp. Clin. Cancer Res., 2018;37(1):78.
2. Effect of telomere and telomerase interactive agents on human tumor and normal cell lines.
   Rha et al.
   Clin.Cancer Res., 2000;6:987
3. Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
   Shammas et al.
   Mol.Cancer Ther., 2003;2:825
4. Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA.
   Wheelhouse et al.
   J.Am.Chem.Soc., 1998;120:3261
5. Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.
   Shi et al.
   J.Med.Chem., 2001;474:4509

Product Datasheets