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TP 472

Catalog #: 6000
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6000/10
TP 472 | CAS No. 2079895-62-6 | Bromodomain Inhibitors
1 Image
Description: Potent BRD9/7 inhibitor

Chemical Name: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

TP 472 is a potent BRD9/7 inhibitor (Kd values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.

Negative Control also available.

Technical Data

M.Wt:
333.38
Formula:
C20H19N3O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2079895-62-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.
Other Product-Specific Information:

Background References

  1. A rationale to target the SWI/SNF complex for cancer therapy.
    Hohmann and Vakoc et al.
    Trends Genet., 2014;30:356

Product Datasheets

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Citations for TP 472

The citations listed below are publications that use Tocris products. Selected citations for TP 472 include:

2 Citations: Showing 1 - 2

  1. The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma.
    Authors: Thomas G Et al.
    Cells  2022;11
  2. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.
    Authors: Gatchalian Et al.
    Nat Commun  2018;9:5139

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