Triacsin C

Catalog #: 2472
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
2472/100U

Triacsin C | CAS No. 76896-80-5 | Synthase/Synthetase Inhibitors

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Description: Inhibitor of acyl-CoA synthetase

Chemical Name: (2E,4E,7E)-2,4,7-Undecatrienal nitrosohydrazone

Purity: ≥95%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Triacsin C is an inhibitor of acyl-CoA synthetase. Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice.

Technical Data

M.Wt:

207.27

Formula:

C₁₁H₁₇N_3O

Solubility:

Soluble to 5 mg/ml in DMSO

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

76896-80-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation.
Tomoda et al.
J.Biol.Chem., 1991;266:4214
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
Mashima et al.
J.Natl.Cancer.Inst., 2005;97:765
ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis
J Chen, C Ding, Y Chen, W Hu, Y Lu, W Wu, Y Zhang, B Yang, H Wu, C Peng, H Xie, L Zhou, J Wu, S Zheng
Oncogenesis, 2020;9(4):42.

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Citation for Triacsin C

The citations listed below are publications that use Tocris products. Selected citations for Triacsin C include:

1 Citation: Showing 1 - 1

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.
Authors: Lancaster Et al.
Cell Metab 2018;27:1096

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