Tropisetron hydrochloride
Chemical Name: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Purity: ≥99%
Biological Activity
Tropisetron hydrochloride is a potent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR. Activates α7Q79G-GlyR chimeric ion channels (EC50 = 38 nM)Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Centrally active 5-HT receptor agonists and antagonists.
Middlemiss and Tricklebank
Neurosci.Biobehav.Rev., 1992;16:75 -
5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake.
Mhatre et al.
Eur.J.Pharmacol., 2004;491:149 -
5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granis. and tropisetron.
Seynaeve et al.
Anticancer Drugs, 1991;2:343 -
Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.
Papke et al.
Bioorg.Med.Chem.Lett., 2004;14:1849
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Citations for Tropisetron hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Tropisetron hydrochloride include:
4 Citations: Showing 1 - 4
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Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
Authors: Otvos Et al.
Respir Physiol Neurobiol 2015;7:2336
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Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism.
Authors: Johnson Et al.
Proc Natl Acad Sci U S A 2015;207:48
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The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.
Authors: Spilman Et al.
Brain Res 2014;1551:25
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Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea.
Authors: Sendin Et al.
Mol Cell Biol 2014;111:1999
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