TTNPB
Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity: ≥98%
Biological Activity
TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity.
Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L
Biochem Biophys Res Commun, 2014;454(4):537-542. -
Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.
Minucci et al.
Proc.Natl.Acad.Sci.U.S.A., 1996;93:1803 -
Arotinoids, a new class of highly active retinoids.
Loeliger et al.
Eur.J.Med.Chem.-Chim.Ther., 1980;15:9 -
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
Hou et al.
Science, 2013;341:651
Product Datasheets
Reconstitution Calculator
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Citations for TTNPB
The citations listed below are publications that use Tocris products. Selected citations for TTNPB include:
7 Citations: Showing 1 - 7
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Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
Authors: Cordeiro Et al.
Structure 2019;
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Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
Authors: Wang Et al.
J Mol Cell Biol 2017;9:338
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ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
Authors: Chronopoulos Et al.
Nature Communications 2016;7:12630
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The lymph node as a new site for kidney organogenesis.
Authors: Francipane and Lagasse
Stem Cells Transl Med 2015;4:295
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Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
Authors: Zhang Et al.
Cell Stem Cell 2015;17:735
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Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
Authors: Thomas and Henry
Br J Pharmacol 2014;386:291
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A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation.
Authors: Tay Et al.
Mol Pharmacol 2010;77:218
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