Home / Additional Nicotinic Receptor Antagonists / (+)-Tubocurarine chloride

(+)-Tubocurarine chloride

Catalog #: 2820
10 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2820/50
(+)-Tubocurarine chloride | CAS No. 57-94-3 | Additional Nicotinic Receptor Antagonists
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Description: nAChR antagonist

Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride

Purity: ≥98%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

Technical Data

M.Wt:
681.65
Formula:
C37H41ClN2O6.HCl
Solubility:
Soluble to 25 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
57-94-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor.
    Pederson and Cohen
    Proc.Natl.Acad.Sci.USA, 1990;87:2785
  2. Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine.
    Peters et al.
    Neurosci.Letts., 1990;110:107
  3. The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons.
    Wotring and Yoon
    Neurosci., 1995;67:293

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Citations for (+)-Tubocurarine chloride

The citations listed below are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:

10 Citations: Showing 1 - 10

  1. Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.
    Authors: Corns Et al.
    Nat Commun  2018;9:4015
  2. Ex vivo Whole-cell Recordings in Adult Drosophila Brain.
    Authors: Roemmich Et al.
    Bio Protoc  2018;8
  3. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
    Authors: Zhu Et al.
    Nat Commun  2017;8:1676
  4. A cellular mechanism for inverse effectiveness in multisensory integration.
    Authors: Truszkowski Et al.
    Elife  2017;6
  5. Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
    Authors: Pinnock Et al.
    BMC Syst Biol  2015;9:30
  6. Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.
    Authors: Zachary and Fuchs
    J Neurosci  2015;35:9701
  7. Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics.
    Authors: Nagel Et al.
    Nat Neurosci  2015;18:56
  8. Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors.
    Authors: Freeman Et al.
    Front Behav Neurosci  2013;110:103
  9. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    J Biol Chem  2012;31:2937
  10. Allosteric block of KCa2 channels by apamin.
    Authors: Lamy Et al.
    J Neurophysiol  2010;285:27067

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