UBP 282

Name: UBP 282
Brand: Tocris Bioscience
SKU: 1765

Catalog #: 1765 Datasheet / COA / SDS

Discontinued Product

1765 has been discontinued.

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UBP 282 | CAS No. 544697-47-4 | AMPA Receptor Antagonists

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Description: Non-NMDA iGluR antagonist; distinguishes between motoneuron and dorsal root kainate receptors

Alternative Names: 3-CBW

Chemical Name: (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

Purity: ≥98%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AMPA and kainate receptor antagonist. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres.

Technical Data

M.Wt:

333.3

Formula:

C₁₅H₁₅N₃O₆

Solubility:

Soluble to 100 mM in 1eq. NaOH and to 25 mM in 1eq. HCl

Purity:

≥98%

Storage:

Store at RT

CAS No:

544697-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists.
More et al.
Br.J.Pharmacol., 2003;138:1093
The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.
More et al.
Br.J.Pharmacol., 2002;137:1125

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